Clouser was a member of NIN from 1994-2000 and was part of the live band on the [[Self Destruct]] and [[Fragility]] tours, as well as collaborating with [[Trent Reznor]] in the studio on various projects. One such collaboration being the ''[[Natural Born Killers Soundtrack|Natural Born Killers]]'' soundtrack on which he aided in recording and producing a new version of "[[Something I Can Never Have]]." His work can also be heard on releases such as ''[[Further Down the Spiral]]'' and ''[[Things Falling Apart]].''
Clouser has also done remixes for various bands, including: White Zombie, [[Marilyn Manson (band)|Marilyn Manson]], Rammstein, Prong, Killing Joke, Type O Negative, Zilch, Schwein, Collide, [[12 Rounds]], Foetus, Meat Beat Manifesto and Esthero.
He has also worked as a composer, scoring the films ''Saw'' (2004), ''Saw II'' (2005), ''Saw III'' (2006), ''Saw IV'' (2007), ''Resident Evil: Extinction'' (2007), ''Death Sentence'' (2007), ''Dead Silence'' (2007), ''Deepwater'' (2005) and ''End Of Days'' (1999), as well as the TV series ''Las Vegas'' (2003 - 2007) and ''Fastlane'' (2005). He is currently the composer for the series ''NUMB3RS''. He also played in the film ''Mooq'' (2004).